Farzad Safari | Microbial Foren | Best Researcher Award

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Dr. Farzad Safari | Microbial Foren | Best Researcher Award

Researcher | Isfahan University of Medical Siences | Iran

Dr. Farzad Safari is a distinguished medical doctor and researcher at the School of Medicine, Isfahan University of Medical Sciences, with specialized expertise in internal medicine, gastroenterology, and nephrology. His scholarly work reflects a deep commitment to advancing diagnostic precision and therapeutic strategies in gastrointestinal and renal disorders, with a particular emphasis on colorectal cancer screening and biomarker discovery. Through extensive research collaborations with multidisciplinary teams, Dr. Safari has contributed to several influential studies exploring innovative screening methodologies that integrate fecal and blood-based diagnostic tests, microRNA profiling, and molecular markers to enhance early cancer detection and reduce the need for invasive procedures. His publications in reputable international journals such as The New England Journal of Medicine, Gastroenterology, BMC Gastroenterology, and Frontiers in Medicine demonstrate his ability to bridge clinical insight with translational research. As a reviewer for respected journals including Annals of Medicine and Surgery, International Journal of Surgery, and Frontiers in Medicine, he upholds rigorous academic standards and contributes to maintaining scientific integrity in medical publishing. Dr. Safari’s contributions not only enrich academic knowledge but also hold meaningful implications for public health policy and global disease prevention strategies, particularly in optimizing colorectal cancer screening programs in diverse populations. His collaborative research ethos, clinical acumen, and dedication to evidence-based medicine position him as a key contributor to the evolving landscape of internal medicine and gastroenterology, advancing both scientific understanding and patient care outcomes on a global scale.

Profiles: Google Scholar | Scopus | ORCID

Publications

1. Safari, F. R. S., & Noursina, A. (2024). Stool and blood DNA tests for colorectal cancer screening. The New England Journal of Medicine.

2. Noursina, A., & Safari, F. (2024). Enhancing colorectal cancer screening specificity by integrating fecal microRNA signature with fecal immunochemical test and fecal occult blood test. Gastroenterology.

3. Ghomashi, N., Safari, F., & Noursina, A. (2023). Reducing the need for colonoscopy with adjusted FIT and FOBT for stool weight and serum Hb levels. Frontiers in Medicine.

4. Soheilipour, M., Noursina, A., Nekookhoo, M., Malekpour, E., Mirzaei, S. A., et al. (2025). The pathobiont role of Akkermansia muciniphila in colorectal cancer: A systematic review. BMC Gastroenterology.

5. Baradaran, A., Mohammadi Jazi, B., Nekookhoo, M., Sabokrooh, Z., et al. (2025). A comprehensive analysis of integrating guaiac fecal occult blood test and fecal immunochemical test for colorectal cancer screening. Journal of Isfahan Medical School.

Introduction of Antibiotic

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Introduction of Antibiotic

Antibiotics are powerful medications used to treat infections caused by bacteria. They work by killing bacteria or inhibiting their growth, helping to cure infections that would otherwise become severe or life-threatening. Antibiotics have revolutionized modern medicine since their discovery, drastically reducing mortality from bacterial infections. However, the misuse and overuse of antibiotics have led to increasing levels of antibiotic resistance, posing a significant threat to global health.

  • Types of Antibiotics:
  1. Broad-spectrum Antibiotics:
    These antibiotics work against a wide variety of bacteria, both Gram-positive and Gram-negative. Examples include:

    • Amoxicillin
    • Tetracycline
    • Ciprofloxacin
  2. Narrow-spectrum Antibiotics:
    These antibiotics target specific types of bacteria. Examples include:

    • Penicillin G (used mainly against Gram-positive bacteria)
    • Vancomycin (used against resistant Gram-positive bacteria)
  3. Bactericidal Antibiotics:
    These kill bacteria by attacking their cell walls or vital cellular functions. Examples include:

    • Penicillin
    • Cephalosporins
    • Aminoglycosides
  4. Bacteriostatic Antibiotics:
    These inhibit bacterial growth by interfering with bacterial protein production or DNA replication. Examples include:

    • Tetracycline
    • Sulfonamides
    • Chloramphenicol
  • How Antibiotics Work:
  • Antibiotics target key processes in bacteria that are essential for their survival and replication. These include:
  • Cell wall synthesis inhibition: Prevents bacteria from forming cell walls, leading to cell death (e.g., Penicillin).
  • Protein synthesis inhibition: Disrupts bacterial ribosomes, which produce proteins essential for cell function (e.g., Tetracycline).
  • DNA replication inhibition: Prevents bacterial DNA replication, halting cell division (e.g., Quinolones).
  • Cell membrane disruption: Damages bacterial cell membranes, leading to cell death (e.g., Polymyxins).

    Examples of Antibiotic-Resistant Bacteria:

    1. Methicillin-resistant Staphylococcus aureus (MRSA): Resistant to many antibiotics, causing serious skin infections.
    2. Vancomycin-resistant Enterococci (VRE): Often found in hospital-acquired infections.
    3. Carbapenem-resistant Enterobacteriaceae (CRE): Highly resistant to most antibiotics and often fatal.
    4. Multidrug-resistant Mycobacterium tuberculosis (MDR-TB): Resistant to the two most powerful anti-TB drugs, requiring complex and prolonged treatment.
  • Understanding and managing animal infectious diseases is crucial for animal health, public health, and maintaining food security.

 

Introduction of Animal Infectious Diseases
Introduction of Animal infectious diseases Animal infectious diseases are illnesses caused by pathogenic microorganisms such as bacteria, viruses, fungi, or parasites that can affect a wide range of animal species.

 

Introduction of Animal Infectious Diseases

Published on by Infectious

Introduction of Animal infectious diseases

Animal infectious diseases are illnesses caused by pathogenic microorganisms such as bacteria, viruses, fungi, or parasites that can affect a wide range of animal species. These diseases can spread through direct contact between animals, contaminated water or food, vectors like insects, or environmental exposure.

Types of Animal Infectious Diseases

Viral Diseases:

Foot-and-Mouth Disease (FMD): Affects cloven-hoofed animals like cattle, sheep, and pigs. It's highly contagious and causes fever, blisters in the mouth and on feet, and can lead to severe economic losses.

Rabies: A fatal viral disease that affects the nervous system of mammals, including humans. It's transmitted through the saliva of infected animals, usually via bites.

Bacterial Diseases:

Anthrax: Caused by Bacillus anthracis, it affects cattle, sheep, and other herbivores, and can be transmitted to humans. It causes severe symptoms like sudden death in animals.

Brucellosis: Affects cattle, goats, and pigs, leading to reproductive issues like abortions. It can also be transmitted to humans, causing flu-like symptoms.

Parasitic Diseases:

Toxoplasmosis: Caused by the parasite Toxoplasma gondii, it can affect most warm-blooded animals, including humans. It often leads to neurological issues and reproductive problems.

Trypanosomiasis (Sleeping Sickness): Caused by Trypanosoma parasites, it's transmitted by tsetse flies and affects both animals and humans, leading to severe neurological issues.

Fungal Diseases:

Ringworm: A skin infection caused by various fungi, it affects many animals, including cattle, dogs, and cats. It causes circular patches of hair loss and skin irritation.

Transmission and Impact

Direct Transmission: Through physical contact, bites, or close proximity.

Indirect Transmission: Via contaminated feed, water, equipment, or bedding.

Vector-Borne Transmission: Carried by insects like ticks, mosquitoes, or flies.

Environmental Transmission: Through contaminated soil, water, or air.

These diseases can lead to significant economic losses in agriculture, reduce productivity, and in some cases, pose serious public health risks due to zoonotic transmission (diseases that can be transmitted from animals to humans).

Prevention and Control

Vaccination: Effective for preventing many viral and bacterial diseases.

Quarantine: Isolating infected animals to prevent the spread of disease.

Good Hygiene Practices: Regular cleaning and disinfection of animal housing, equipment, and environment.

Vector Control: Managing and reducing the population of disease-carrying insects.

Regular Monitoring and Surveillance: Early detection and response to outbreaks can prevent widespread infection.

Understanding and managing animal infectious diseases is crucial for animal health, public health, and maintaining food security.

 

Introduction of Animal Infectious Diseases
Introduction of Animal infectious diseases Animal infectious diseases are illnesses caused by pathogenic microorganisms such as bacteria, viruses, fungi, or parasites that can affect a wide range of animal species.
Introduction of Antimicrobial
  Introduction of Antimicrobial Antimicrobials are substances or agents used to kill or inhibit the growth of microorganisms, which include bacteria, viruses, fungi, and parasites. They are essential in treating
Introduction of Antibiotic
Introduction of Antibiotic Antibiotics are powerful medications used to treat infections caused by bacteria. They work by killing bacteria or inhibiting their growth, helping to cure infections that would otherwise