Filip Štrbac – Antibiotics – Best Researcher Award

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Filip Štrbac - Antibiotics - Best Researcher Award

University of Belgrade - Institute for Multidisciplinary Research - Serbia

AUTHOR PROFILE 

ORCID
GOOGLE SCHOLAR

EARLY ACADEMIC ROOTS 🌱

Dr. Filip Štrbac’s academic journey in the field of veterinary medicine began with distinction and purpose. Born in Novi Sad, Serbia, his natural aptitude for science was evident during his time at “Jovan Jovanović Zmaj” High School, where he pursued natural sciences and mathematics. This foundation led him to the Faculty of Agriculture at the University of Novi Sad, where he enrolled in the integrated Veterinary Medicine program. Graduating with an impressive GPA of 9.58, his undergraduate thesis explored blood plasma proteins in poultry, showcasing an early interest in biochemistry and physiological processes, both of which intersect with the study of Antibiotics. His passion for veterinary pharmacology and parasitology only deepened as he advanced to doctoral studies. From 2017 to 2023, Dr. Štrbac conducted rigorous research on the anthelmintic efficacy of essential oils, a project intricately linked with the search for plant-based alternatives to conventional Antibiotics. His PhD thesis was not only a scientific contribution to parasitology but also a forward-looking effort to reduce reliance on synthetic Antibiotics in animal health. This pivotal work set the stage for his future investigations into Antibiotics resistance, phytotherapy, and sustainable veterinary interventions—issues central to both public and animal health in the 21st century.

RESEARCH PASSIONS IN VETERINARY SCIENCE 🔬

Dr. Filip Štrbac’s research career is anchored in a multidisciplinary exploration of parasitology, veterinary pharmacology, and phytotherapy—fields deeply connected with the current global discourse on Antibiotics. At the University of Novi Sad and later at the Institute for Multidisciplinary Research in Belgrade, his projects consistently addressed the challenge of Antibiotics resistance by exploring alternatives from nature, particularly essential oils with anthelmintic properties. His groundbreaking in vitro and in vivo studies on gastrointestinal nematodes in sheep examined the pharmacodynamics of plant-based compounds, providing comparative data with traditional Antibiotics. These investigations not only validated the efficacy of natural compounds but also contributed to understanding the mechanisms by which certain pathogens develop resistance to conventional Antibiotics. His collaborative work across European institutions, including research stays in Italy and Spain, enabled a cross-cultural scientific exchange on sustainable veterinary practices. Moreover, his leadership roles in international COST Actions, such as COMBAR and MedPlants4Vet, allowed him to advance studies on minimizing the ecological impact of synthetic Antibiotics. As a result, Dr. Štrbac’s work straddles the boundaries of pharmacology and ecology, advancing veterinary science while actively promoting a global reduction in the use of Antibiotics, thereby contributing to the worldwide effort to curb antimicrobial resistance.

CONTRIBUTIONS TO ANIMAL HEALTH AND THERAPEUTICS 🐑

One of Dr. Filip Štrbac’s most significant contributions lies in his innovative approaches to animal health care, specifically through the development of phytopharmacological strategies that reduce dependence on synthetic Antibiotics. His detailed work on essential oils such as peppermint, oregano, and winter savory demonstrated measurable anthelmintic effects against sheep gastrointestinal nematodes, offering a functional and ecologically safer alternative to traditional Antibiotics. With over ten influential publications in peer-reviewed journals, including Frontiers in Veterinary Science and BMC Veterinary Research, Dr. Štrbac has shaped the veterinary landscape toward sustainable therapeutics. These studies provided compelling evidence of how plant-derived compounds can serve as frontline agents against parasitic infections, particularly in livestock—a sector often overburdened with Antibiotics usage. His interdisciplinary methodology, combining in vitro assays, field trials, and pharmacological modeling, reflects a commitment to scientific rigor and real-world application. Furthermore, his active role in environmental projects such as ENVIRANT underscores his dedication to understanding how Antibiotics affect both treated animals and surrounding ecosystems. Dr. Štrbac’s holistic view of veterinary pharmacology—bridging animal welfare, environmental health, and microbial resistance—positions him as a leader in redefining therapeutic practices beyond conventional Antibiotics-based protocols in veterinary medicine.

GLOBAL COLLABORATIONS AND SCIENTIFIC NETWORKS 🌍

Dr. Filip Štrbac has strategically positioned himself within the global scientific community through active collaboration and leadership in numerous European research networks, focusing on sustainable solutions to challenges posed by overuse of Antibiotics. His work in the COST Actions—such as COMBAR, MedPlants4Vet, ENVIRANT, and BeSafeBeeHoney—has addressed the pressing issue of Antibiotics resistance in livestock systems. By engaging in these consortia, Dr. Štrbac contributed to developing regulatory frameworks and scientific roadmaps for integrating phytotherapeutic alternatives to conventional Antibiotics. His research stays in Spain and Italy, particularly at the University of Naples Federico II and the CREMOPAR Center, were instrumental in aligning Serbian veterinary research with broader EU standards. These exchanges enabled him to co-develop diagnostic protocols and efficacy tests for plant-based treatments in parasitic infections, targeting pathogens commonly treated with Antibiotics. Through these partnerships, he has been a vocal advocate for integrating traditional herbal knowledge with modern veterinary science, a philosophy increasingly seen as vital for reducing overreliance on Antibiotics globally. As an expert evaluator for COST project proposals and a reviewer for high-impact journals in pharmacology and veterinary medicine, he continues to influence how the international community approaches responsible Antibiotics usage, reinforcing a shift toward sustainable, evidence-based parasitic disease control.

SCHOLARSHIP, PUBLICATIONS, AND RECOGNITION 🏅

Dr. Filip Štrbac’s scholarly output reflects both depth and innovation, especially in the context of exploring non-conventional therapies as viable complements or substitutes for Antibiotics. With more than ten peer-reviewed publications focused on essential oils and their pharmacological efficacy, he has emerged as a recognized figure in phytotherapy and veterinary parasitology. His articles often appear in high-impact journals such as Frontiers in Veterinary Science, Veterinary Sciences, and Pakistan Veterinary Journal, where he compares plant-based anthelmintics to standard Antibiotics. The scope of his work includes ovicidal, larvicidal, and adulticidal activities of bioactive compounds, bringing new insights into sustainable parasite control. His excellence has been acknowledged through numerous academic honors, including the Best Student of Generation award and national PhD scholarships funded by the Serbian Ministry of Education. These accolades underscore his scholarly commitment and reflect his aim to address Antibiotics resistance in both national and international contexts. Moreover, his role as a reviewer for leading scientific journals and as an expert evaluator for COST proposals further solidifies his status as a thought leader on alternatives to Antibiotics. Each recognition he has received is a testament to his mission: to challenge traditional paradigms and advance veterinary therapeutics beyond the limits of Antibiotics.

IMPACT ON FUTURE VETERINARY PRACTICE 🚀

Dr. Filip Štrbac’s innovative work has set the foundation for a future in veterinary medicine where sustainability and precision replace dependency on conventional Antibiotics. His research not only expands the therapeutic arsenal with botanically derived anthelmintics but also introduces new frameworks for understanding the ecological implications of prolonged Antibiotics usage. His in vivo trials using essential oils such as oregano and peppermint highlight how natural compounds can achieve comparable or even superior efficacy to traditional Antibiotics without promoting microbial resistance. This groundbreaking evidence supports a paradigm shift in how veterinarians, farmers, and pharmaceutical developers approach parasite management. Through his involvement in multi-national EU projects like eco2adapt and INTACT, Dr. Štrbac promotes the integration of ecosystem-based adaptation into veterinary care, with a special emphasis on minimizing Antibiotics spillover into the environment. His work directly contributes to the One Health movement, bridging human, animal, and environmental health through the reduction of Antibiotics overuse. Future veterinary practitioners, researchers, and policy-makers stand to benefit immensely from the models, data, and strategies he is pioneering. In redefining therapeutic protocols through science-backed phytotherapy, Dr. Štrbac is reshaping the trajectory of global veterinary medicine away from over-reliance on Antibiotics and toward a resilient, sustainable future.

LEGACY AND VISION FOR ANTIBIOTICS ALTERNATIVES 🌿

Dr. Filip Štrbac’s legacy is already being etched into the evolving narrative of modern veterinary pharmacology, especially through his contributions to Antibiotics alternatives. By identifying and validating the therapeutic potential of essential oils and plant extracts, he champions a future where natural remedies complement or replace synthetic Antibiotics in combating parasitic diseases. His vision is deeply aligned with global initiatives targeting antimicrobial resistance, environmental sustainability, and holistic health. As the principal investigator in several international and national projects, Dr. Štrbac continuously advocates for bridging ethnopharmacological traditions with cutting-edge scientific validation. His comprehensive approach—spanning phytochemical analysis, in vivo trials, and regulatory integration—makes his work a blueprint for future Antibiotics research. Beyond his publications and laboratory contributions, his mentorship of young scientists and his engagement in science diplomacy position him as a transformative figure in veterinary medicine. His future goals include expanding phytotherapy databases, developing standardized protocols for plant-based treatments, and influencing policy for regulated, sustainable Antibiotics use. In essence, Dr. Štrbac’s enduring impact will be measured not only by the reduced reliance on Antibiotics but also by the healthier animals, ecosystems, and communities that benefit from his science-driven, nature-inspired approach to veterinary health.

NOTABLE PUBLICATION

  • Title: Anthelmintic resistance in gastrointestinal nematodes of sheep: Current situation and novel strategies
    Authors: Filip Štrbac, Dragica Stojanović
    Journal: Conference Paper – 2024, FeMeSPRumNS
  • Title: Physiological role, pharmacokinetics and pharmacodynamics of niacin in cows
    Authors: Kosta Petrović, Dragica Stojanović, Filip Štrbac, Talija Hristovska
    Journal: Conference Paper – 2024, FeMeSPRumNS
  • Title: Botanical Control of Parasites in Veterinary Medicine
    Authors: Filip Štrbac, Slobodan Krnjajić, Dragica Stojanović, Nikolina Novakov, Antonio Bosco, Nataša Simin, Radomir Ratajac, Slađan Stanković, Giuseppe Cringoli, Laura Rinaldi
    Journal: Book Chapter – One Health Triad, Vol. III, 2023
  • Title: In Vitro and In Vivo Anthelmintic Efficacy of Peppermint (Mentha x piperita L.) Essential Oil against Gastrointestinal Nematodes of Sheep
    Authors: Filip Štrbac, Slobodan Krnjajić, Dragica Stojanović, Radomir Ratajac, Nataša Simin, Dejan Orčić, Laura Rinaldi, Elena Ciccone, Maria Paola Maurelli, Giuseppe Cringoli et al.
    Journal: Frontiers in Veterinary Science – 2023-08-10
  • Title: A Potential Anthelmintic Phytopharmacological Source of Origanum vulgare (L.) Essential Oil against Gastrointestinal Nematodes of Sheep
    Authors: Filip Štrbac, Slobodan Krnjajić, Maria Paola Maurelli, Dragica Stojanović, Nataša Simin, Dejan Orčić, Radomir Ratajac, Kosta Petrović, Goran Knežević, Giuseppe Cringoli et al.
    Journal: Animals – 2022-12-22

Anara Babayeva – Antibiotics – Best Researcher Award

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Anara Babayeva - Antibiotics - Best Researcher Award

Mugla Sıtkı Kocman University - Turkey

AUTHOR PROFILE 

GOOGLE SCHOLAR

EARLY ACADEMIC ROOTS 🌱

Anara Babayeva, born in Baku, Azerbaijan, on February 9, 1993, embarked on her academic journey with a passion for biology that would soon shape a compelling scientific career. After completing high school at A.S. Xalilov No. 263, she earned her bachelor's degree in biology from Azerbaijan State Pedagogical University. Her academic curiosity led her to Turkey, where she pursued and completed her master’s degree in biology at Muğla Sıtkı Koçman University. It was during this period that Anara began cultivating her deep scientific interest in molecular biology, microbiology, and the emerging field of functional genomics. The foundation she built during these formative years prepared her to engage in highly complex studies involving transcriptomics, metabolomics, and proteomics—fields crucial in the global fight against resistant bacteria. Even as a student, she was drawn to innovative research areas, especially the use of natural compounds and novel molecules like boron-derived antibiotics. Her early education served as a launchpad for numerous national and international research projects focused on bacterial gene expression, antimicrobial resistance, and metabolic profiling. Her work consistently demonstrated both a profound understanding of biological systems and a visionary approach toward leveraging antibiotics for therapeutic and diagnostic breakthroughs.

ADVANCED SCIENTIFIC EXPLORATIONS 🔬

At the graduate and post-graduate levels, Anara Babayeva immersed herself in the intricacies of biotechnology and molecular research. Her focus sharpened on developing novel methodologies to understand how antibiotics, particularly boron-containing compounds like epetraborole, interact with pathogenic strains such as Escherichia coli. At Muğla Sıtkı Koçman University, she became an active researcher in various TÜBİTAK and BAP-funded projects, contributing significantly to studies investigating bacterial gene responses, antimicrobial resistance, and phenolic compounds. Anara's efforts included advanced proteomic and transcriptomic analyses, often utilizing nano LC-MS/MS, 2D gel electrophoresis, and microarray platforms. Her expertise expanded through work on functional genomics, including KEIO mutant screening and ASKA clone analysis, highlighting her unique ability to decode complex genetic systems. Through these cutting-edge methods, Anara explored the biochemical and genomic impact of antibiotics on cellular networks. This phase of her career showcased not just technical proficiency but also a bold drive to innovate in diagnostics and treatment methodologies. Her work during this period not only contributed to scientific literature but also provided a deeper understanding of how natural compounds and synthetic antibiotics could serve as the cornerstone of next-generation antimicrobial strategies.

GROUNDBREAKING RESEARCH IN ANTIBIOTICS 🧪

Anara Babayeva’s scientific pursuits have consistently centered around the dynamic and urgent field of antibiotics research. Her hallmark contributions involve the investigation of epetraborole, a boron-containing experimental drug, and its mechanisms against bacterial strains. She has taken a leading role in several TÜBİTAK-funded projects examining how specific genes and proteins in Escherichia coli respond to antimicrobial stress, using technologies like NMR metabolomics and proteomics to detect subtle molecular changes. In particular, her research revealed novel gene targets and metabolic pathways affected by boron-based antibiotics, advancing our understanding of bacterial resistance and tolerance mechanisms. Through transcriptomic profiling, she has mapped how gene overexpression or deletion can modify bacterial behavior under drug pressure. These insights are essential in combating multidrug-resistant organisms, which pose a growing threat to global health. Anara’s ability to synthesize bioinformatics data with wet-lab experimentation has propelled her work to the forefront of functional antibiotic discovery. Her pioneering studies underscore how interdisciplinary approaches can unlock powerful antimicrobial solutions, turning theoretical findings into practical applications. By bridging molecular biology and clinical microbiology, she continues to redefine how antibiotics are conceptualized and tested in modern laboratories.

NATURAL COMPOUNDS AND ANTIMICROBIAL INNOVATION 🌿

In addition to synthetic antibiotics, Anara Babayeva has conducted extensive research on natural compounds with antimicrobial properties. Her investigations into Turkish propolis, phenolic acids, and even sea urchin extracts highlight her interest in exploring bioactive molecules from diverse ecosystems. She played key roles in studies examining the antimicrobial and anticancer effects of substances like Dracunculus vulgaris, Rosularia serrata, Amanita virosa, and Trichaptum biforme. These experiments often employed metabolomic profiling and transcriptomic studies to determine how natural extracts affect microbial survival, with findings suggesting that nature-derived compounds could complement traditional antibiotics or even pave the way for new drug classes. By examining how compounds such as propolis influence nucleic acid metabolism and protein expression in E. coli, Anara has contributed important data to the field of natural product pharmacology. Her research also sheds light on how bacteria develop resistance or tolerance to both synthetic and natural antimicrobial agents. This dual approach—studying both commercial antibiotics and bioactive compounds—illustrates her comprehensive understanding of microbial defense strategies and her commitment to uncovering sustainable, multifaceted antimicrobial therapies.

ACCOLADES AND ACADEMIC CONTRIBUTIONS 🏆

Throughout her career, Anara Babayeva has earned widespread recognition for her contributions to molecular biology and antibiotics research. Her scholarly work has been featured in respected journals such as Frontiers in Life Sciences and Related Technologies, Journal of Applied Microbiology, and International Journal of Peptide Research and Therapeutics. She has authored and co-authored impactful studies on epetraborole, bacterial gene responses, and antimicrobial resistance. Moreover, Anara has presented her findings at prominent international conferences, where her work on boron-based antibiotics, gene expression, and metabolomics has drawn praise from the academic community. Her participation in events such as the International Proteomics Congress and multiple TÜBİTAK conferences demonstrates her active engagement in scientific dialogue. Her reputation as an innovative and meticulous researcher has made her a respected figure in the antibiotic discovery field. Notably, her efforts are not limited to publication—she has been actively involved in mentoring, conducting experimental designs, and guiding younger researchers in the lab. These contributions ensure that her knowledge and passion for antibiotics continue to influence future scientific exploration and public health advancements.

SCIENTIFIC IMPACT AND GLOBAL REACH 🌍

Anara Babayeva’s research has transcended national boundaries, contributing valuable insights to the global scientific community’s understanding of antibiotics. Her interdisciplinary methodology—integrating genomics, proteomics, and metabolomics—has made significant strides in elucidating how bacteria interact with both synthetic and natural antimicrobial agents. By targeting genes associated with resistance and metabolic adaptation, she has helped pinpoint vulnerable molecular pathways, offering promising new targets for therapeutic development. Anara’s findings not only contribute to scientific journals but also inform broader discussions on antibiotic stewardship and resistance management worldwide. Her work is increasingly relevant in the age of rising antibiotic-resistant infections, especially as health organizations emphasize the need for next-generation antimicrobial drugs. Collaborations with international partners and participation in bilateral research projects further highlight her influence beyond Turkey and Azerbaijan. Her data on propolis and boron-derived antibiotics have implications for pharmaceutical development, bioengineering, and public health strategies. Anara’s science-driven advocacy promotes rational drug design and emphasizes a balance between innovation and sustainability in the use of antibiotics, making her a crucial voice in the global effort to protect the efficacy of life-saving antimicrobial therapies.

VISION FOR THE FUTURE OF ANTIBIOTICS RESEARCH 🔭

Looking ahead, Anara Babayeva envisions a future where advanced technologies converge to develop smarter, safer, and more sustainable antibiotics. Her ongoing research focuses on identifying novel gene-drug interactions, using tools like CRISPR screening, AI-driven bioinformatics, and NMR-based metabolomics. With a strong foundation in functional genomics and microbial systems biology, she aims to build integrated models that predict bacterial responses to emerging drug candidates. She is particularly interested in the synergy between synthetic molecules and natural extracts, which could minimize resistance development while enhancing drug efficacy. Future projects include studying microbial ecology under antimicrobial stress and developing biosensors for antibiotic susceptibility testing. Anara is also committed to mentoring a new generation of scientists who can carry forward the fight against antibiotic resistance. As antibiotics become an increasingly precious resource, her research will help redefine how they are developed, prescribed, and preserved. Her legacy is poised to be one of scientific rigor and visionary leadership—pioneering not just new compounds but also a paradigm shift in how the world understands and utilizes antibiotics for both human and environmental health.

NOTABLE PUBLICATION

  • Title: NMR metabolomics analysis of Escherichia coli cells treated with Turkish propolis water extract reveals nucleic acid metabolism as the major target
    Authors: ES Elgin, ŞS Çatav, A Babayeva, H Kim, E Dibek, B Çöl, YK Chae, ...
    Journal: Journal of Applied Microbiology

 

  • Title: Bor içeren bazı biyoaktif bileşikler
    Authors: E Dibek, A Babayeva, MS Kürkçü, NA Çöl, B Çöl
    Journal: Journal of Boron

 

  • Title: Genome-wide screen of Escherichia coli Keio mutant line identifies genes related to propolis effect
    Authors: E Dibek, A Babayeva, ES Elgin, MS Kürkçü, B Çöl
    Journal: European Food Research and Technology

 

  • Title: The Cytotoxic Effects of Turkish Bee Venom (Apis mellifera) on Selected Cancer Cell Lines
    Authors: A Babayeva, E Dibek, İ Kıvrak, B Çöl
    Journal: International Journal of Peptide Research and Therapeutics

 

  • Title: Genome-wide Screening of the Escherichia coli Keio Knockout Collection Identifies Genetic Determinants of Epetraborole Hypersusceptibility
    Authors: A Babayeva, B Çöl
    Journal: European Journal of Clinical Microbiology & Infectious Diseases

Introduction of Antimicrobial

Posted on by Infectious

 

Introduction of Antimicrobial

Antimicrobials are substances or agents used to kill or inhibit the growth of microorganisms, which include bacteria, viruses, fungi, and parasites. They are essential in treating infections caused by these microbes, preventing their spread, and protecting health. Here’s a more detailed breakdown:

Types of Antimicrobials:

Antibiotics: Specifically target bacteria. Examples include penicillin, amoxicillin, and tetracycline. Antibiotics can kill bacteria or stop them from growing, making them crucial in treating bacterial infections like pneumonia, strep throat, and urinary tract infections.

Antivirals: These target viruses. Examples include acyclovir, which is used to treat herpes, and oseltamivir (Tamiflu), used to treat influenza. Antivirals work by interfering with the virus’s ability to replicate inside the host’s cells.

Antifungals: These are used to combat fungal infections. Examples include fluconazole, used to treat yeast infections, and terbinafine, used for athlete’s foot. Antifungals work by disrupting the cell walls of fungi or interfering with their metabolism.

Antiparasitics: These target parasites, which can cause diseases like malaria or intestinal worm infections. Examples include chloroquine for malaria and albendazole for worm infestations.

How Antimicrobials Work:

Cell Wall Disruption: Some antimicrobials weaken or destroy the microbe’s cell wall or membrane, leading to cell death. For example, penicillin disrupts the formation of bacterial cell walls.

Protein Synthesis Inhibition: Some antimicrobials interfere with the microbe’s ability to produce essential proteins, stopping their growth and reproduction. Tetracycline, for instance, inhibits protein synthesis in bacteria.

DNA Replication Interference: Some antimicrobials prevent microbes from replicating their DNA, which is necessary for their reproduction. Fluoroquinolones, for example, block bacterial DNA replication.

Metabolic Pathway Disruption: Some target specific biochemical pathways essential for the microbe’s survival. For instance, sulfonamides inhibit the synthesis of folic acid in bacteria, which is crucial for their growth.

Importance of Antimicrobials:

Medical Use: Antimicrobials are vital in treating infections, performing surgeries (by preventing infections), and managing chronic diseases that weaken the immune system, like cancer or HIV/AIDS.

Agricultural Use: They are also used in agriculture to prevent and treat infections in livestock, ensuring food safety and animal health.

Food Safety: Antimicrobials are used to prevent the contamination of food products by harmful microbes, extending shelf life and reducing the risk of foodborne illnesses.

Challenges:

Antimicrobial Resistance (AMR): The overuse and misuse of antimicrobials, such as not completing prescribed courses of antibiotics or using them for non-bacterial infections, have led to the development of resistant strains of microbes. These resistant strains can survive and thrive even in the presence of antimicrobials, making infections harder to treat and increasing the risk of disease spread, severe illness, and death.

Antimicrobials play a crucial role in modern medicine and public health, but their effectiveness is threatened by the growing problem of resistance, which requires careful management and stewardship.