Charlene Pillay – Antibiotic – Best Researcher Award

Charlene Pillay - Antibiotic - Best Researcher Award

Durban University of Technology - South Africa 

AUTHOR PROFILE

ORCID

🎓 EARLY ACADEMIC PURSUITS

Dr. Charlene Pillay’s academic journey began at the University of KwaZulu-Natal, where she pursued a passion for microbiology, culminating in a PhD in 2012. Her doctoral thesis focused on microbiologically influenced corrosion—an intersection of microbiology and material science—under the guidance of Professor Johnson Lin. This work explored the impact of nitrate sources on steel corrosion in simulated systems, laying a strong foundation for her future research interests. She earlier completed her MSc, BSc Honours, and BSc in Microbiology at the same institution. These academic milestones not only reflect her dedication but also shaped her into a specialist with deep-rooted scientific curiosity. Her early academic accomplishments were punctuated by significant research, blending microbiology with environmental and industrial applications. This robust educational background has since served as the bedrock of her teaching and research endeavors. Driven by curiosity and scholarly discipline, Dr. Pillay’s academic formation set the tone for a prolific scientific career.

👩‍🔬 PROFESSIONAL ENDEAVORS IN EDUCATION

Currently serving as a Senior Lecturer at Durban University of Technology (DUT), Dr. Charlene Pillay is deeply engaged in academic mentorship, curriculum development, and student supervision. Since 2015, she has delivered lectures, coordinated work-integrated learning, and facilitated essential industry-academic linkages. Her role extends beyond the classroom, involving the academic supervision of students placed in industrial settings, thus reinforcing experiential learning. Before joining DUT, she held various teaching and technical positions at the University of KwaZulu-Natal, including AdHoc Lecturer roles in Bacteriology and Advanced Bacteriology, and a stint as Laboratory Technician. These roles helped her develop both instructional expertise and technical skills crucial in laboratory education. Her teaching philosophy blends theory with hands-on experience, equipping students with a holistic understanding of microbiology. Through her academic contributions, she has established herself as a dynamic educator committed to nurturing future scientists and bridging academia with real-world applications in biosciences.

🧪 CONTRIBUTIONS AND RESEARCH FOCUS

Dr. Pillay’s research focus reflects a unique synergy between microbiology, corrosion science, and ethnopharmacology. Initially concentrated on microbiologically influenced corrosion, her scholarly journey evolved to include antimicrobial research, bioremediation, and computational drug discovery using traditional medicinal plants. She has supervised numerous Honours and Master’s research projects addressing diverse topics such as bacterial modulation, type 2 diabetes therapy, soil bioremediation, and plant-based antimicrobial agents. Her publication portfolio spans high-impact journals like Archives of Microbiology, BMC Genomics, and Metabolites, showcasing work on quorum sensing modulators, gut microbiome studies, and therapeutic validation of plant-derived compounds. Notably, her interdisciplinary investigations bridge computational modeling with in vitro validations. Dr. Pillay’s research significantly contributes to understanding microbial behavior, the utility of plant secondary metabolites in health, and sustainable biomedical solutions. Her work remains rooted in addressing real-world health challenges through science-driven innovation, positioning her as a leading voice in applied microbiological research.

🏆 ACCOLADES AND RECOGNITION

Dr. Charlene Pillay’s scholarly excellence has earned her multiple accolades that underscore her research impact and scientific promise. She received the prestigious Ivan Oligvie Award from the Corrosion Institute of Southern Africa in 2008 for her early work in corrosion science. In 2009, she was honored with the SASM-Bio2Biz Travel Award, followed by a local conference travel award from the Faculty of Science and Agriculture at UKZN in 2011. These recognitions mark pivotal moments in her career, affirming the quality and relevance of her research. Beyond formal awards, her consistent publication record in reputable scientific outlets and active participation in interdisciplinary research teams further validate her professional standing. Through her collaborative work with colleagues like Professors Sabiu and Lin, Dr. Pillay continues to earn respect in both academic and applied science spheres. Her accolades reflect not only academic merit but also her growing influence as a respected contributor in microbiological and biomedical sciences.

🌿 IMPACT THROUGH SCIENTIFIC INNOVATION

Dr. Pillay's research has profound implications for environmental sustainability and public health, particularly through her investigations into plant-based therapeutics and microbial ecology. By integrating traditional medicinal knowledge with modern cheminformatics, she contributes to the discovery of bioactive compounds with the potential to combat non-communicable diseases like diabetes. Her studies on plant secondary metabolites, such as flavonoids and phenolic acids, are pivotal in developing alternative therapeutic strategies. Likewise, her research into bacterial biofilms and quorum sensing provides critical insights into managing antimicrobial resistance. The environmental aspect of her work—focusing on biodegradation of contaminants and soil microbiome dynamics—highlights her commitment to ecological well-being. These innovative approaches not only advance scientific understanding but also propose sustainable, low-cost healthcare and environmental solutions. Her work inspires future scientists to pursue research with tangible societal benefits, thereby enhancing her broader impact across academic, medical, and ecological domains.

👥 MENTORSHIP AND SCHOLARLY INFLUENCE

As a postgraduate supervisor, Dr. Charlene Pillay has significantly shaped the next generation of microbiologists and biomedical researchers. Her mentorship extends to BTech, Honours, and Master's students, with projects spanning from bioremediation techniques to computational drug modeling. She is known for encouraging innovation and critical thinking, guiding students through complex scientific methods and interdisciplinary topics. Many of her mentees have focused on real-world challenges such as antimicrobial resistance, plant-based drug development, and gut microbiome studies. Her mentorship fosters independence and scientific rigor, qualities evident in the student theses she has overseen. Through these scholarly interactions, she cultivates a research culture grounded in curiosity, integrity, and relevance. Her influence extends beyond academia into healthcare and biotechnology industries via her well-trained graduates. This legacy of mentorship underscores her dual role as both educator and enabler, investing in people as passionately as she invests in scientific exploration.

🔮 LEGACY AND FUTURE CONTRIBUTIONS

Dr. Charlene Pillay envisions a legacy rooted in transformative science and inclusive education. Her ambition to become a full professor with a thriving cohort of successful postgraduates reflects her long-term dedication to academic leadership. With aspirations to secure major research funding, she aims to expand her work in ethnopharmacology and microbial pathogenesis, focusing on groundbreaking, plant-based interventions for global health challenges. Her evolving research portfolio suggests forthcoming contributions in personalized medicine, antimicrobial strategies, and microbial genomics. As a thought leader in integrating traditional knowledge with modern science, she continues to set new standards for interdisciplinary research. Dr. Pillay’s legacy is one of innovation, mentorship, and impact—building bridges between past wisdom and future science. Her future contributions are poised to influence not only academia but also public health policy, environmental management, and scientific education, making her a pivotal figure in the global scientific community.

NOTABLE PUBLICATION

Title: A metagenomic investigation of the faecal RNA virome structure of asymptomatic chickens obtained from a commercial farm in Durban, KwaZulu-Natal province, South Africa
Authors: Nwokorogu, Vivian C.; Pillai, Santhosh; San, James E.; Pillay, Charlene; Nyaga, Martin M.; Sabiu, Saheed
Journal: BMC Genomics (2024)

Title: Cheminformatics Identification and Validation of Dipeptidyl Peptidase-IV Modulators from Shikimate Pathway-Derived Phenolic Acids towards Interventive Type-2 Diabetes Therapy
Authors: Balogun, Fatai Oladunni; Naidoo, Kaylene; Aribisala, Jamiu Olaseni; Pillay, Charlene; Sabiu, Saheed
Journal: Metabolites (2022)

Title: Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B
Authors: Rampadarath, Athika; Balogun, Fatai Oladunni; Pillay, Charlene; Sabiu, Saheed
Journal: Journal of Diabetes Research (2022)

Title: Poultry gut health - microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies
Authors: Aruwa, Christiana Eleojo; Pillay, Charlene; Nyaga, Martin M.; Sabiu, Saheed
Journal: Journal of Animal Science and Biotechnology (2021)

Title: The impact of additional nitrates in mild steel corrosion in a seawater/sediment system
Authors: Pillay, Charlene; Lin, Johnson
Journal: Corrosion Science (2014)

Somdeb Bose Dasgupta – Microbial Pathogenesis and Virulence – Best Researcher Award

Somdeb Bose Dasgupta - Microbial Pathogenesis and Virulence - Best Researcher Award

IIT Kharagpur - India

AUTHOR PROFILE 

SCOPUS

EARLY ACADEMIC PURSUITS 🎓

Dr. Somdeb Bose Dasgupta began his scientific journey with a B.Sc in Physiology, Chemistry, and Zoology from City College, University of Calcutta, graduating with first-class honors in 2001. He pursued an M.Sc in Biophysics & Molecular Biology from Rajabazar Science College, University of Calcutta, and again secured first-class distinction. His academic rigor culminated in a Ph.D. in Molecular Parasitology from CSIR-IICB and Jadavpur University in 2009, where he was awarded the Best Thesis Award. During his doctoral years, Dr. Dasgupta delved deep into the molecular machinery of parasitic organisms, setting the foundation for a career that would be defined by his dedication to host-pathogen interactions. The exceptional clarity and originality of his doctoral research earned him early recognition in India’s scientific community, establishing a trajectory toward pioneering work in infectious diseases and immunology, especially concerning neglected tropical diseases like Leishmaniasis and Tuberculosis.

PROFESSIONAL ODYSSEY 🌍

Following his doctorate, Dr. Dasgupta expanded his scientific horizon through a postdoctoral fellowship at the University of Basel’s Biozentrum in Switzerland, from 2009 to 2014, where he worked on macrophage-pathogen interactions. This global exposure refined his research methodologies and enriched his understanding of molecular immunology. He then returned to India to contribute as an Assistant Professor at IIT (BHU) Varanasi from 2014 to 2016, before joining IIT Kharagpur in the Department of Biotechnology in 2016. At IIT Kharagpur, he rose to the position of Assistant Professor Grade I and became a pivotal figure in both undergraduate and postgraduate teaching. His courses span Molecular Biology, Neurophysiology, Biochemistry, and Bioprocess Engineering, nurturing the next generation of biotechnologists. His professional odyssey reflects a balance between international research excellence and a deep-rooted commitment to Indian scientific development. Throughout, he has maintained a clear vision: to translate basic science into therapeutic and diagnostic breakthroughs against life-threatening infectious diseases.

RESEARCH FOCUS 🔬

Dr. Dasgupta’s research lies at the intersection of molecular immunology, cellular microbiology, and genome editing. His lab investigates host-pathogen dynamics, especially in Mycobacterium tuberculosis and Leishmania donovani infections—diseases of critical importance to the Indian subcontinent. Utilizing CRISPR/Cas9 technologies, his team uncovers how host enzymes, particularly kinases and phosphatases, are manipulated by pathogens to ensure survival. His group is innovating host-directed therapeutics to bypass drug resistance by reactivating immune responses and restoring macrophage functionality. His approach includes drug repurposing strategies—like testing tricyclic antidepressants for anti-leishmanial use—and developing novel diagnostics for drug-resistant TB. Additionally, Dr. Dasgupta studies how parasitic infections influence phagosome maturation and immune modulation. His projects explore everything from biochemical pathway elucidation to advanced nanocarrier-based drug delivery systems. By combining cellular, biochemical, and genomic strategies, his lab offers crucial insights into both fundamental disease biology and translational medicine, with the aim of improving public health outcomes across endemic regions.

PIONEERING CONTRIBUTIONS 🧪

Over his career, Dr. Dasgupta has contributed over 38 research articles, five book chapters, and 25 conference proceedings, with many featured in high-impact journals like PNAS, FEBS Journal, and PLOS Pathogens. His pioneering findings—such as the discovery of how S-nitrosylation of mycobacterial Protein Kinase G (PknG) aids pathogen survival—have received global attention, including journal cover highlights and editor’s choice selections. At the forefront of translational research, he developed groundbreaking assays to study host-pathogen phospho-signaling, designed nanocarrier systems for immunomodulatory drug delivery, and repurposed common drugs into potential antiparasitic treatments. His innovations in CRISPR-based gene editing of host and pathogen genomes have redefined therapeutic targets. Further, his role in establishing India’s hybrid BSL-III facility at IIT Kharagpur has paved the way for safe, cutting-edge research on high-risk pathogens. Collectively, Dr. Dasgupta’s work bridges discovery and application, positioning him as a vanguard of molecular parasitology and infectious disease biology.

AWARDS AND RECOGNITION 🏅

Dr. Dasgupta’s scholarly excellence has been widely acknowledged. He was honored with the prestigious INSA Young Scientist Award in 2011 for contributions to biophysics and biochemistry, followed by the coveted DBT-Ramalingaswamy Fellowship in 2015. His postdoctoral research earned him the EMBO Long Term Fellowship in 2009, reflecting international acclaim. He has received multiple Best Poster Awards at national and international symposia, including the Annual Post-doc Retreats in Switzerland and the National Congress of Parasitology in India. His publications have been featured on journal covers and spotlighted for editorial distinction. He also received a DBT-CTEP Travel Award to attend the World Congress in Infectious Diseases in London, showcasing his global scientific presence. These accolades underscore both the depth and societal impact of his research. Through sustained excellence in discovery, innovation, and mentorship, Dr. Dasgupta has become a beacon in the field of molecular microbiology and immunopathology, inspiring peers and proteges alike.

IMPACT AND INFLUENCE 🌐

Dr. Dasgupta’s influence extends beyond laboratory research into public health, diagnostics, and therapeutic development. His contributions are instrumental in tackling antimicrobial resistance—one of modern medicine’s gravest challenges. By advancing host-directed therapies and creating rapid point-of-care diagnostic tools, he directly impacts clinical strategies for TB and Leishmaniasis. His leadership in major government-funded projects—ranging from ICMR, DST, DBT, to SERB—demonstrates trust in his ability to deliver translational outcomes. His work has informed national health priorities and contributed to India’s strategic push toward self-reliance in infectious disease control. As a mentor and educator, he shapes future scientists, embedding translational thinking in their academic DNA. His integrated approach, which combines molecular biology, nanotechnology, and immunology, sets a benchmark for interdisciplinary biomedical research in India. Through his visionary projects and collaborations, Dr. Dasgupta is not only solving today's biomedical problems but also laying the groundwork for long-term scientific resilience and healthcare innovation.

LEGACY AND FUTURE HORIZONS 🚀

Dr. Dasgupta’s legacy lies in transforming how we understand and combat chronic infectious diseases in resource-limited settings. His work champions a paradigm shift—from pathogen-centric drug design to host-targeted intervention, which offers sustainable solutions in the face of evolving drug resistance. The upcoming years promise even greater impact: his team is pioneering biosensors for non-invasive TB detection and leveraging liposomal drug delivery platforms for improved efficacy. With multiple ICMR-backed projects underway, including ENLIGHTEN—a non-invasive latent TB detection initiative—Dr. Dasgupta continues to chart untraveled paths in diagnostic science. He also plays a central role in shaping high-containment laboratory infrastructure to safely study dangerous pathogens. His foresight, collaborative spirit, and relentless pursuit of translational relevance ensure that his contributions will endure in both academic and clinical domains. Dr. Somdeb Bose Dasgupta is poised to remain a cornerstone of biomedical innovation, where his science continues to illuminate pathways toward global health equity.

NOTABLE PUBLICATION 

 Article Title:
Resolving the polycistronic aftermath: Essential role of topoisomerase IA in preventing R-loops in Leishmania
Authors: P. Das, A. Hazra, S. Saha, H.K. Majumdar, S. BoseDasgupta
Journal: The Journal of Biological Chemistry, 2024

 Article Title:
Gelatin-decorated Graphene oxide: A nanocarrier for delivering pH-responsive drug for improving therapeutic efficacy against atherosclerotic plaque
Authors: S.K. Yadav, S. Das, A. Lincon, S.K. Ray, S.C. Das
Journal: International Journal of Pharmaceutics, 2024