Yi HSin Wang | Antibiotic | Best Researcher Award

Assist Prof Dr. Yi HSin Wang , Chung Shan Medical University, Taiwan.

Assist Prof Dr. Yi Hsin Wang is a dedicated researcher specializing in antibiotic discovery and development. With a strong academic foundation in microbiology and pharmacology, she has contributed significantly to the understanding of antibiotic resistance mechanisms and the identification of novel antimicrobial agents. Her work focuses on developing innovative strategies to combat bacterial infections, making a profound impact on public health. Yi Hsin has published numerous articles in peer-reviewed journals and has presented her research at international conferences, showcasing her commitment to advancing the field of antibiotic research. Her dedication to scientific excellence and her contributions to antibiotic development make her a deserving candidate for the Best Researcher Award.

Profile:

Scopus Profile

Education

Assist Prof Dr. Yi-Hsin Wang pursued his academic journey at Chung Shan Medical University, beginning with a Bachelor of Science degree in Medical Applied Chemistry from 2008 to 2012. He then advanced to the Institute of Medicine at the same university, completing a Master of Science degree from 2012 to 2014 under the guidance of Professors Jinghua Tsai Chang and Shiang-Suo Huang. Building upon his research foundation, Yi-Hsin continued his studies in the Institute of Medicine, where he earned his Ph.D. from 2014 to 2018, with Professors Jinghua Tsai Chang and Shiang-Suo Huang as his advisors once again.

Experience

Assist Prof Dr. Yi-Hsin Wang currently holds the position of Assistant Professor in the Department of Physiology at Chung Shan Medical University’s School of Medicine (2022.08–present). Previously, Wang served as a Postdoctoral Researcher in the Department of Pharmacology at China Shan Medical University’s School of Medicine (2019.08–2022.07) and in the Graduate Institute of Acupuncture Science at China Medical University (2018.09–2019.07), with a strong focus on physiology, pharmacology, and acupuncture science throughout their academic and research career.

Skills

Assist Prof Dr. Yi-Hsin Wang possesses a range of experimental skills, including expertise in creating animal models for myocardial infarction and ischemic stroke. Additionally, Wang is proficient in Western blotting, gelatin zymography, and immunohistochemistry, each essential for analyzing protein expression, enzyme activity, and tissue-specific antigen localization.

Awards

Assist Prof Dr. Yi-Hsin Wang has received notable awards for contributions to biomedical sciences, including the Young Scientist Travel Award at the 9th FAOPS Congress (2019) in Japan and 2nd place in the Poster Award at the 33rd Joint Annual Conference of Biomedical Sciences (2018) in Taiwan.

Research Skills

Assist Prof Dr. Yi-Hsin Wang research expertise encompasses a diverse range of fields, including cardiology, with a focus on cardioprotection, and extends to neuroscience, particularly in the area of neuroprotection. His work also addresses the mechanisms underlying ischemia/reperfusion injury, contributing to a deeper understanding of both brain and cardiovascular physiology.

Top Note Publications

Title: Dunaliella salina Alga Protects against Myocardial Ischemia/Reperfusion Injury by Attenuating TLR4 Signaling

Authors: Tsai, C.-F., Lin, H.-W., Liao, J.-M., … Wang, M., Huang, S.-S.
Year: 2023
Citations: 4

Title: Lumbrokinase Regulates Endoplasmic Reticulum Stress to Improve Neurological Deficits in Ischemic Stroke

Authors: Wang, Y.-H., Liao, J.-M., Chen, K.-M., … Tsai, C.-F., Huang, S.-S.
Year: 2022
Citations: 5

Title: Activation of Peripheral TRPM8 Mitigates Ischemic Stroke by Topically Applied Menthol

Authors: Huang, S.-S., Su, H.-H., Chien, S.-Y., … Lee, H.-H., Chen, Y.-H.
Year: 2022
Citations: 14

Title: In Situ Slow-Release Recombinant Growth Differentiation Factor 11 Exhibits Therapeutic Efficacy in Ischemic Stroke

Authors: Su, H.-H., Yen, J.-C., Liao, J.-M., … Chen, Y.-H., Huang, S.-S.
Year: 2021
Citations: 5

Title: Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Authors: Tsai, C.-F., Su, H.-H., Chen, K., … Wang, Y.-H., Huang, S.-S.
Year: 2021
Citations: 27

Introduction of Antibiotic

Antibiotics are powerful medications used to treat infections caused by bacteria. They work by killing bacteria or inhibiting their growth, helping to cure infections that would otherwise become severe or life-threatening. Antibiotics have revolutionized modern medicine since their discovery, drastically reducing mortality from bacterial infections. However, the misuse and overuse of antibiotics have led to increasing levels of antibiotic resistance, posing a significant threat to global health.

Types of Antibiotics:

Broad-spectrum Antibiotics:
These antibiotics work against a wide variety of bacteria, both Gram-positive and Gram-negative. Examples include:

Amoxicillin
Tetracycline
Ciprofloxacin

Narrow-spectrum Antibiotics:
These antibiotics target specific types of bacteria. Examples include:

Penicillin G (used mainly against Gram-positive bacteria)
Vancomycin (used against resistant Gram-positive bacteria)

Bactericidal Antibiotics:
These kill bacteria by attacking their cell walls or vital cellular functions. Examples include:

Penicillin
Cephalosporins
Aminoglycosides

Bacteriostatic Antibiotics:
These inhibit bacterial growth by interfering with bacterial protein production or DNA replication. Examples include:

Tetracycline
Sulfonamides
Chloramphenicol

How Antibiotics Work:

Antibiotics target key processes in bacteria that are essential for their survival and replication. These include:

Cell wall synthesis inhibition: Prevents bacteria from forming cell walls, leading to cell death (e.g., Penicillin).

Protein synthesis inhibition: Disrupts bacterial ribosomes, which produce proteins essential for cell function (e.g., Tetracycline).

DNA replication inhibition: Prevents bacterial DNA replication, halting cell division (e.g., Quinolones).

Cell membrane disruption: Damages bacterial cell membranes, leading to cell death (e.g., Polymyxins).

Examples of Antibiotic-Resistant Bacteria:

Methicillin-resistant Staphylococcus aureus (MRSA): Resistant to many antibiotics, causing serious skin infections.
Vancomycin-resistant Enterococci (VRE): Often found in hospital-acquired infections.
Carbapenem-resistant Enterobacteriaceae (CRE): Highly resistant to most antibiotics and often fatal.
Multidrug-resistant Mycobacterium tuberculosis (MDR-TB): Resistant to the two most powerful anti-TB drugs, requiring complex and prolonged treatment.

Understanding and managing animal infectious diseases is crucial for animal health, public health, and maintaining food security.